The purpose of this study is to evaluate the clinical safety·efficacy of the Huvitz Fundus Camera HWSO-1 by comparing fundus color images, fundus autofluorescence images, optical coherence tomography images, and optical coherence angiography images with other devices(Heidelberg Spectralis HRA2, Topcon 3D OCT) in  ocular disease and healthy eyes.
Ophthalmic diseases are not amenable to biopsy due to the characteristics of the eye, so imaging tests play an important role in the diagnosis, treatment, follow-up, and research of many diseases, and recently, devices that analyze multiple types of images simultaneously are preferred. 
Among the various imaging tests in ophthalmology, fundus photography, fundus autofluorescence imaging, optical coherence tomography, optical coherence angiography, fluorescein angiography, and indocyanine angiography are commonly used in daily practice. Fundus photography is a method of taking natural-color photos of the vitreous, retina, optic nerve, choroid, etc. using a camera, and is an important test for patient diagnosis and health promotion. In recent years, fundus photography has been performed in various ways such as red-free ophthalmoscopy, blue reflectance image, near-infrared image, and fundus autofluorescence image (FAF) using various filters or Scanning Laser Ophthalmoscope (SLO). 
Optical coherence tomography (OCT) is a diagnostic technique that obtains information from the inside of tissues by measuring the difference in intensity and the delay in echo time of the reflected light after shining a certain wavelength of light on the tissue, and then recombines it into a two-dimensional or three-dimensional image to observe the cross-section of the tissue in high resolution at the micrometer level. OCT has the great advantage of being able to observe changes in retinal cross-section in vivo at high resolution due to disease progression and treatment, and it also has the advantage of being able to make objective and quantitative measurements in a short time with less inter-observer variation than other tests.
Optical coherence tomography and optical coherence tomography angiography (OCTA) have been widely used for choroidal vascular assessment because they are noninvasive methods of imaging choroidal blood flow and retinal structures and reduce patient discomfort compared to fluorescein angiography, which uses contrast media. Fluorescein angiography and indocyanine angiography, which use contrast media to determine the vascular status of the retina and choroid, are being used more frequently as scanning laser ophthalmoscopy and wide-field technology have improved.
This study aims to evaluate the clinical efficacy of a multifunctional ophthalmic diagnostic imaging device developed with the support of Korea Medical Device Development Fund (KMDF) by comparing and analyzing fundus photographs, optical coherence tomography, and optical coherence angiography images taken with existing commercially available ophthalmic imaging equipment.
The study will include 14 adults with healthy eyes and 42 adults with diseased eyes. After obtaining written informed consent from all study participants, refraction, visual acuity, intraocular pressure, anterior segment examination with slit lamp, and fundus examination will be performed. Only eyes that meet the pre-selected criteria will be scanned with the test and control devices.
This is a single-group, open-label clinical trial with no randomization or blinding, and participants will only visit once and complete the study in one day.
Participants are aware that both control and test devices will be applied, and investigator make an arbitrary order of application of the control and test devices.
After the test is completed, compare and analyze the image quality of fundus color images, fundus autofluorescence images, optical coherence tomography images, and optical coherence angiography images obtained from the test device and the control device.

Cohort/Group Label

Those who need to take a fundus photography.

Cohort/Group Description

Scanning Laser Ophthalmicscope color image(SLO color image)
Fundus AutoFluorescence image(FAF image)
Optical Coherence Tomogrphy image(OCT image)
Optical Coherenece Tomography Angiography(OCTA image)

Not collect nor Archive

Patients who need to take fundus photographs due to eye diseases such as retinal disease or glaucoma and who need to take fundus photographs for eye exam.

Sample size based on a commercially available fundus camera with a sensitivity of 75%, specificity of 94%, and a dropout rate of 10%.
(14 healthy eyes and 42 diseased eyes were recruited).
People who have given written consent to participate in the study and meet predefined inclusion/exclusion criteria.

Gender

Age

Description

1) Healthy eyes
- Adults between the ages of 19 and 80 years old
- Those who have given written consent to participate in the study
- General healthy eyes: Spherical Equivalent within ±6.00D, corrected visual acuity of 0.25 or better, intraocular pressure of 21mmHg or less, no clinically significant abnormal findings in the anterior segment/ fundus, eye without a surgery(excluding cataracts and refractive surgery) and ocular diseases eyes that will not effect the result under investigator's decision.

2) Ocular disease eyes
- Adults between the ages of 19 and 80 years old
- Those who have given written consent to participate in the study
- subjects who require fundus photography due to eye disease such as retinal disease or glaucoma.

1) Pregnant and lactating women
2) Eyes with a media opacity(corneal opacity, severe cataract, vitreous opacity, etc.) that  may affect the result by the investigator's decision.
3) Eyes deemed inappropriate by the investigator.

Sensitivity and specificity of retinal abnormalities in Scanning Laser Ophthalmicscope color image

Within 12 months of study completion

Agreement of abnormalities on macular disease between scanning laser ophthalmicscope color images of test device and control device

Within 12 months of study completion

Image quality of the test device in scanning laser ophthalmoscope color images

Within 12 months of study completion

Sensitivity and specificity of abnormalities on scanning laser ophthalmoscopy fundus autofluorescence images 

Within 12 months of study completion

Agreement of retinal abnormalities on scanning laser ophthalmoscope fundus autofluorescence images between test and control devices

Within 12 months of study completion

Image quality of the test device in scanning laser ophthalmoscopy fundus autofluorescence images

Within 12 months of study completion

Central macular thickness and Segmentation Error in Optical Coherence Tomography Images

Within 12 months of study completion

Regional vessel density of superficial capillary plexus layer in optical coherence tomography angiography

Within 12 months of study completion