This is a non-control prospective observational study of patients with dyspepsia who visit a hospital, to check the types and effects of herbal medicines used in patients with categorized of "phlegm-fluid retention", evaluate the usefulness of the evaluation tool, and change intestinal microflora for 2 weeks Observe.

The purpose of this clinical study was to investigate clinical observation information in patients with functional dyspepsia between the ages of 19 to 65.
If the research subject agrees in writing to participate in the clinical research in person, the clinical case information will be collected after confirming whether the research target is suitable for the selection criteria and exclusion criteria.

[Primary effectiveness evaluation]
1. Intestinal microflora: The rate of change in the proportion of microorganisms by evaluation point (after 0, 1 week)

[Secondary effectiveness evaluation]
1.NDI-K: Score change amount by evaluation point (after 0, 2 weeks)
2.NDI-K quality of life: score change by evaluation point (after 0, 2 weeks)
3.phlegm-fluid retention pattern questionnaire: Amount of change in score by evaluation point (after Screening, after 1 or 2 weeks)
4.VAS: The amount of change in score by evaluation point (after 0, 1, 2 weeks)
5.BMI: The amount of change in score by evaluation point (after 0, 1, 2 weeks)

Cohort/Group Label

The patients with functional dyspepsia diagnosis with categorized of "Dam-Eum"

Cohort/Group Description

An Observational Study on Effect of Herbal Medicine Treatment and Change of Gut Microbiome in Functional Dyspepsia Patients with Categorized of "phlegm-fluid retention"

: DNA Collect & Archive: Sample without DNA

stool

In order to treat functional dyspepsia at the Daejeon Oriental Medical Hospital of Daejeon University, consent is obtained and the study is conducted if the patient meets the criteria.

Rome Ⅳ Criteria, phlegm-fluid retention pattern questionnaire , laboratory test

Gender

Age

Description

1. Age from 19 yrs to 65 yrs of man or woman
2. Subjects who have normal opinion in endoscopy within 2 years
3. Subjects who meet the definition of ROME Ⅳ criteria
4. Subjects who are categorized with "phlegm-fluid retention" pattern functional dyspepsia using instrument of pattern questionnaire for "phlegm-fluid retention"
5. Subjects who give voluntarily an written consent for the trial

1. Subjects who have histories of gastrointestinal surgery (except appendectomy)
2. Subjects who have gastrointestinal bleeding, intestinal obstruction, gastrointestinal perforation
3. Subjects who have gastroduodenal ulcer, gastric cancer, colorectal cancer current or prior within 2 years
4. Subjects who is undergoing treatment for eradication of H.pylori
5. Subjects who have liver tumor, liver cirrhosis, chronic renal failure, congestive heart failure
6. High serum AST, ALT(> 2-fold of UNL) or high serum creatinine(≥ 2.0mg/dL)
7. Subjects who are in period of pregnancy or lactation, or planning to have a baby
8. Subjects who drink more than three times a week or often drink excessively.
9. Subjects who are mentally unhelthy to follow the protocol properly

Intestinal microflora: Changes in the ratio of microorganisms by evaluation point

Base line week, 1 weeks later

Score change for Questionnair of NDI-K

Base line week, 2 weeks later

Score change for Questionnair of NDI-K quality of life

Base line day, 2 weeks

Score change for Questionnaire of "phelgm-fluid retention"

Screening day, 1 week, 2 weeks later

Score change for VAS

Base line day, 1 week, 2 weeks

Score change for BMI

Base line day, 1 week, 2 weeks